AZD-4635 Cas:1321514-06-0

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Product Description:

Product Name: AZD-4635 CAS NO: 1321514-06-0

 

Synonyms:

HTL-1071;

1,2,4-Triazin-3-amine, 6-(2-chloro-6-methyl-4-pyridinyl)-5-(4-fluorophenyl)-;

6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine;

 

Chemical & Physical Properties:

Appearance: Solid or powder

Assay :≥99.0%

Boiling Point: 491.5±55.0℃(Predicted)

Density: 1.387±0.06 g/cm3 (Predicted)

PKa: 1.75±0.63 (Predicted)

 

Imaradenant (AZD4635, HTL1071) is an oral A2AR antagonist that can bind to human A2AR with a Ki value of 1.7 nM, which is more than 30 times more selective for A2AR than other adenosine receptors. In CHO cells stably expressing human A2AR, AZD4625 inhibited cAMP production with IC50 values of 0.79, 10.0 and 142.9 nM in the presence of 0.1, 1 and 10 μmadenosine, respectively. Inhibition of A2AR by AZD4625 can reduce tumor load and enhance anti-tumor immunity.

 

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