axitinib Cas:319460-85-0

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axitinib

Synonyms:
AG-013736 N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide
AXITINIB
Axtinib
AVERMECTINB
[14C]-Axitinib
Inlyta
Axitinib (usan)
 
Molecular Formula: C22H18N4OS
Molecular weight: 386.47000

Appearance and properties: off-white solid
Density: 1.35 g/cm3
Boiling point: 668.9ºC at 760 mmHg
Melting point: 213-215ºC
Flash point: 358.3ºC
Refractive index: 1.728

Uses: Axitinib is a multi-target tyrosine kinase inhibitor, inhibiting VEGFR1, VEGFR2, VEGFR3, PDGFRβ with IC50 values of 4, 20, 4, 2 nM, respectively.

Item Specification USP35 Result
Appearance Pale-yellow to off-white powder Off white powder
Solubility Soluble in dilute hydrochloric acid and dimethyl sulfoxide, slightly soluble in N, Ndimethylformamide, very slightly soluble in methanol or acetonitrile, almost insoluble in water. Complies
Identification UV Complies
HPLC Complies
Related Substances Individual impurity:≤0.2% 0.10%
Total impurities:≤1.0% 0.33%
Loss on drying ≤1.0% 0.45%
Residue on ignition ≤0.1% 0.06%
Heavy Metals ≤20ppm Complies
Assay 98.0%- 102.0% 99.96%
Conclusion : Complies with Enterprise standard




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