axitinib Cas:319460-85-0

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Uses: Axitinib is a multi-target tyrosine kinase inhibitor, inhibiting VEGFR1, VEGFR2, VEGFR3, PDGFRβ with IC50 values of 4, 20, 4, 2 nM, respectively.

Item	Specification USP35	Result
Appearance	Pale-yellow to off-white powder	Off white powder
Solubility	Soluble in dilute hydrochloric acid and dimethyl sulfoxide, slightly soluble in N, Ndimethylformamide, very slightly soluble in methanol or acetonitrile, almost insoluble in water.	Complies
Identification	UV	Complies
	HPLC	Complies
Related Substances	Individual impurity:≤0.2%	0.10%
	Total impurities:≤1.0%	0.33%
Loss on drying	≤1.0%	0.45%
Residue on ignition	≤0.1%	0.06%
Heavy Metals	≤20ppm	Complies
Assay	98.0%- 102.0%	99.96%
Conclusion :	Complies with Enterprise standard

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