axitinib Cas:319460-85-0

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AG-013736 N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide
Axitinib (usan)
Molecular Formula: C22H18N4OS
Molecular weight: 386.47000

Appearance and properties: off-white solid
Density: 1.35 g/cm3
Boiling point: 668.9ºC at 760 mmHg
Melting point: 213-215ºC
Flash point: 358.3ºC
Refractive index: 1.728

Uses: Axitinib is a multi-target tyrosine kinase inhibitor, inhibiting VEGFR1, VEGFR2, VEGFR3, PDGFRβ with IC50 values of 4, 20, 4, 2 nM, respectively.

Item Specification USP35 Result
Appearance Pale-yellow to off-white powder Off white powder
Solubility Soluble in dilute hydrochloric acid and dimethyl sulfoxide, slightly soluble in N, Ndimethylformamide, very slightly soluble in methanol or acetonitrile, almost insoluble in water. Complies
Identification UV Complies
HPLC Complies
Related Substances Individual impurity:≤0.2% 0.10%
Total impurities:≤1.0% 0.33%
Loss on drying ≤1.0% 0.45%
Residue on ignition ≤0.1% 0.06%
Heavy Metals ≤20ppm Complies
Assay 98.0%- 102.0% 99.96%
Conclusion : Complies with Enterprise standard

Market News:We’ve been in the vaccine space for more than 20 years and the impact of [Covid-19] on our revenue was really minor, says Franco. We’re proud of what we have done, but when you produce tens of millions [of pieces] every day, Covid is just one of several businesses. Benzene, 1-(1-methylethyl)-4-(2-methyl-2-phenylpropyl)- manufacturer.One of the engineered IgM antibodies, IGM-6268, demonstrated a significantly increased potency against the original SARS-CoV-2 and emerging variants such as the current U.K., South African, and Brazilian variants of concern (VOC) and variants of interest (VOI) 11β,21-dihydroxy-6α-methyl-17α-propionyloxy-1,4-pregnadiene-3,20-dione supplier.GEM has also partnered with Good360 & Walmart to ensure that every relocated family has move in essentials like bedding, towels, small appliances, tableware, cutlery, glassware and cookware. In addition, each relocated family in the program will receive our GEM Bstrong, Good360, and Walmart ‘Welcome Home Kits’ consisting of new sheets, towels, silverware, pots and pans sets, small appliances and basic move in goods. Transportation of goods provided by GEM transportation partner UC Group ( Pentanenitrile, 2,4-dichloro-2-fluoro-5,5-dimethoxy-4-methyl-, (R*,R*)- producer.

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