Aureobasidin A Cas:127785-64-2

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Product Description:

Product Name: Aureobasidin A CAS NO: 127785-64-2

 

Synonyms:

Cyclo[L-Phe-N-methyl-L-Phe-L-Pro-L-aIle-N-methyl-L-Val-L-Leu-N-methyl-β-hydroxy-L-Val-[(3R)-D-Hmp-]-N-methyl-L-Val-];

LY-295337;

Aureobasidin A (9CI);

 

Chemical & Physical Properties:

Appearance: Powder

Assay :≥99.0%

Density: 1.19g/cm3

Boiling Point: 1229.1℃ at 760 mmHg

Flash Point: 697.1℃

Refractive Index: 1.574

Vapor Pressure: 0mmHg at 25℃

 

Aureobasidin A is a cyclic depsipeptide that is produced byfermentation in cultures of Aureobasidium pullulan.Aureobasidin A acts as a tight-binding noncompetitive inhibitorof the enzyme inositol phosphorylceramide synthase(IPC synthase), which is an essential enzyme for fungalsphingolipid biosynthesis. A unique structural feature of theaureobasidins is the N-methylation of four of seven amide nitrogenatoms. The lack of tautomerism dictated by N-methylationmay contribute to forming a stable solution conformerthat is shaped somewhat like an arrowhead, the presumed biologicallyactive conformation of aureobasidin-A.The pradimycins and benanomycins are naphthacenequinonesthat bind mannan in the presence of Ca2+ to disrupt the cell membrane in pathogenic fungi. Both demonstrate good in vitro and in vivo activity againstCandida spp. and C. neoformans clinical isolates.

 

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