Alpha,alpha-Diphenyl-4-piperidinomethanol Cas:115-46-8

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Alpha,alpha-Diphenyl-4-piperidinomethanol

Product Description:

Product Name: alpha,alpha-Diphenyl-4-piperidinomethanol CAS NO: 115-46-8

 

Synonyms:

Azacyclonol;

α,α-Diphenyl-4-piperidinomethanol;

Diphenyl(piperidin-4-yl)methanol;

 

Chemical & Physical Properties:

Appearance: White to light beige crystalline powder

Assay :≥99.00%

Density: 1.103g/cm3

Boiling Point: 445.5℃ at 760mmHg

Melting Point: 160-163℃

Flash Point: 142℃

Refractive Index: 1.584

Stability: Stable at room temperature in closed containers under normal storage and handling conditions.

Storage Condition: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Vapor Pressure: 1.02E-08mmHg at 25℃

 

Safety Information:

RTECS: TN0470000

Safety Statements: S24/25

HS Code: 29333999

Risk Statements: R36/37/38

Hazard Code: Xi

 

α-(4-Piperidyl)benzhydrol is a key intermediate in the synthesis of Fexofenadine. Azacyclonol, also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals.Target: OthersAzacyclonol is a drug which is a so-called ataractive, or agent which diminishes hallucinations in psychotic individuals. The formation of Azacyclonol in human intestinal microsomes is linear with respect to time up to 60 min. The rates of formation of Azacyclonol increases linearly with microsomal protein concentration up to 2 mg/mL. The apparent Km and Vmax values of Azacyclonol are 0.82 μM and 60 pmol/min/mg protein in microsomes from human liver [1]. The formation of Azacyclonol and terfenadine alcohol from terfenadine is confirmed to be catalyzed predominantly by CYP3A(4) isozyme, and the ratio of the rate of terfenadine alcohol formation to that of Azacyclonol is 3:1 [2]. The amount of Azacyclonol eliminated renally increases on average 2-fold after rifampin dosing [3].

 

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