AC-220 Cas:950769-58-1

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Product Description:

Product Name: AC-220 CAS NO: 950769-58-1

 

Synonyms:

1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[6-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea;

N-[5-(1,1-Dimethylethyl)-3-isoxazolyl]-N”-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]urea;

 

Chemical & Physical Properties:

Appearance: White powder

Assay :≥99.0%

Density: 1.39±0.1 g/cm3 (Predicted)

PKa: 12.59±0.70 (Predicted)

Index of Refraction: 1.691

 

Quizartinib (AC220) is a small molecule receptor tyrosine kinase inhibitor that is currently under development by Ambit Biosciences for the treatment of acute myeloid leukaemia. Its molecular target is FLT3, also known as CD135 which is a proto-oncogene.

Flt3 mutations are among the most common mutations in acute myeloid leukaemia due to internal tandem duplication of Flt3. The presence of this mutation is a marker of adverse outcome.

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

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