Tert-butyl N-[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]carbamate Cas:247068-82-2

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Product Description:

Product Name:

tert-butyl N-[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]carbamate CAS NO: 247068-82-2

 

Synonyms:

Boc-leucine-epoxyketone;

Carfilzomib intermediate;

Boc-L-leucine epoxyketone;

 

Chemical & Physical Properties:

Appearance: White to off-white powder

Assay :≥99.0%

Density: 1.1±0.1 g/cm3

Boiling Point: 369.8±37.0 ℃ at 760 mmHg

Flash Point: 177.5±26.5 ℃

Vapor Pressure: 0.0±0.8 mmHg at 25℃

Index of Refraction: 1.472

PKa: 11.08±0.46 (Predicted)

 

Safety Information:

Signal Word: Warning

Hazard Statement: H302

Precautionary Statements: P280-P305+P351+P338

 

PR171 intermediates (BOC protected) can be used as pharmaceutical intermediates. tert-Butyl ((S)-4-Methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate is an intermediate of Carfilzomib (C183460) which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

 

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