7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one Cas:199327-61-2

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Product Description:

Product Name: 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one CAS NO: 199327-61-2

 

Synonyms:             

Getitinib interMediate;

7-Methoxy-6-[3-(4-morpholinyl)propoxy]-4(3H)-quinazolinone;

Gefitinib iMpurity F;

 

Chemical & Physical Properties:

Appearance: White Solid

Assay :≥99.0%

Density: 1.327 g/cm3

Boiling Point: 519.53℃ at 760 mmHg

Flash Point: 268.002℃

Refractive Index: 1.611

Vapor Pressure: 0mmHg at 25℃

 

Safety Information:

HS Code: 2934999090

 

7-Methoxy-6-[3-(4-morpholinyl)propoxy]-4(3H)-quinazolinone is an impurity of gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibited the growth of egF-stimulated tumor cells (IC50 was 54 nM) and blocked autophosphorylation of EGFR in EGF-stimulated tumor cells. Gefitinib can also induce autophagy. Gefitinib has anti-tumor activity .

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

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