(7-methoxy-4-oxo-1H-quinazolin-6-yl) Acetate Cas:179688-53-0

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Product Description:

Product Name: (7-methoxy-4-oxo-1H-quinazolin-6-yl) acetate CAS NO: 179688-53-0

 

Synonyms:

6-Acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one;

6-Acetoxy-7-methoxy-4-quinazolinol;

3,4-dihydro-4-oxo-6-acetyloxy-7-methoxy-quinazoline;

 

Chemical & Physical Properties:

Appearance: Brown solid powder

Assay :≥99.0%

Density: 1.39

Boiling Point: 452.391℃ at 760 mmHg

Melting Point: 293℃

Flash Point: 227.398℃

Refractive Index: 1.612

Vapor Pressure: 0mmHg at 25℃

 

Safety Information:

HS Code: 2933990090

 

3, 4-dihydro-7-methoxy-4-oxy quinazoline-6-alcohol acetate is a key intermediate for the synthesis of EGFR inhibitor Gefitinib and pan-HER inhibitor Poziotinib and other anti-tumor small molecules. 3, 4-dihydro-7-methoxy-4-oxy quinazoline-6-alcohol acetate can be used as a pharmaceutical synthesis intermediate, can be prepared from 6-hydroxy-7-methoxy-4-ketoquinazoline-as the reaction material, can be used to prepare the intermediate 7-methoxy-6-acetoxy-4-chloroquinazoline-7-methoxy. 3, 4-dihydro-7-methoxy-4-oxy quinazoline-6-alcohol acetate is a white to light brown solid with strong inhibitory activity against VEGFR-2/HDAC and human breast cancer cell line MCF-7. Mainly used in pharmaceutical synthesis intermediates and cosmetics.

 

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