We are 5-chloro-4-hydroxy-1H-pyridin-2-one CAS:103766-25-2 manufacturer and supplier in China, Pls send inquiry of to info@nbinno.com of visit www.nbinno.com our official website should you have any interests
Product Description:
Product Name: 5-chloro-4-hydroxy-1H-pyridin-2-one CAS NO: 103766-25-2
Synonyms:
2,4-dihydroxy-5-chloropyridine;
5-Chloro-2,4-pyridinediol;
5-Chloro-2,4-dihydroxypyridine;
Chemical & Physical Properties:
Appearance: Off-white solid
Assay :≥99.0%
Density: 1.56 g/cm3
Boiling Point: 281.9℃ at 760 mmHg
Melting Point: 274℃
Flash Point: 124.3℃
Refractive Index: 1.617
Vapor Pressure: 0.000408mmHg at 25℃
Storage Condition: Refrigerator
Safety Information:
Hazard Class: 3
Safety Statements: S16; S26; S33; S36/37/39
HS Code: 2942000000
WGK Germany: 1
Packing Group: II
RIDADR: UN 2985 3/PG 2
Risk Statements: R11; R14; R34
Hazard Codes: F; C
Gimeracil(Gimestat) is an inhibitor of dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine including 5-fluorouracil in the blood; inhibits homologous recombination.IC50 Value: Target: DPYDin vitro: Gimeracil had radiosensitizing effects by partially inhibiting homologous recombination (HR) in the repair of DNA double strand breaks. Tail moments in neutral comet assay increased in gimeracil-treated cells. Gimeracil restrained the formation of foci of Rad51 and replication protein A (RPA), whereas it increased the number of foci of Nbs1, Mre11, Rad50, and FancD2. Gimeracil did not sensitize DPYD-depleted cells. Gimeracil inhibited DNA DSB repair. It did not sensitize cells deficient in HR but sensitized those deficient in NHEJ. In SCneo assay, Gimeracil reduced the frequency of neo-positive clones. Additionally, it sensitized the cells in S-phase more than in G0/G1.in vivo:
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