4-(4-Chlorophenyl)piperidin-4-ol Cas:39512-49-7

We are 4-(4-Chlorophenyl)piperidin-4-ol CAS:39512-49-7 manufacturer and supplier in China, Pls send inquiry of to info@nbinno.com of visit www.nbinno.com our official website should you have any interests

Product Description:

Product Name: 4-(4-Chlorophenyl)piperidin-4-ol CAS NO: 39512-49-7

 

Synonyms:

4-(p-Chlorophenyl)-4-piperidinol;

4-Hydroxy-4-(4-chlorophenyl)piperidine;

4-Piperidinol, 4-(4-chlorophenyl)-;

 

Chemical & Physical Properties:

Appearance: White to creamy-white crystalline powder

Assay :≥99.0%

Density: 1.216 g/cm3

Boiling Point: 344.5℃ at 760 mmHg

Melting Point: 139-141℃

Flash Point: 162.1℃

Water Solubility: 340 mg/L (20℃)

Refractive Index: 1.6000 (estimate)

Stability: Stable under normal temperatures and pressures

Storage Condition: Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Storage Temp. : Refrigerator

 

Safety Information:

HS Code: 29333999

Hazard Codes: Xn,Xi

WGK Germany: 3

Risk Statements: R22; R36/37/38

Safety Statements: S26-S37/39

 

4-(p-Chlorophenyl)-4-piperidinol is obtained from 4-chloro-α-methylstyrene ([1712-70-5]) by cyclization, salting, addition, and hydrolysis. 1. Cyclization and salting 4-chloro-α-methylstyrene was added to a mixture of ammonium chloride and formaldehyde and reacted at about 60℃ until the reaction solution was clarified. Then add methanol, react at 45℃ for 4h, steam out methanol, add concentrated hydrochloric acid, react at 40-50℃ for half an hour, react at 95-100℃ for 4h, and leave overnight. Add liquid base to pH 10-11. Extraction with toluene, recovery of toluene under reduced pressure, Chemicalbook residual solution diluted with acetone, added acetic acid to pH 7, crystallization, filtration, acetone washing, drying, 4-p-chlorobenzene 1,2,3, 6-tetrahydropyridine acetate. 2. Addition and hydrolysis The acetate salt was dissolved in glacial acetic acid, dissolved in hydrogen bromide gas at 30℃, crystallized after saturation, and filtered to 4-p-chlorobenzen-4-bromopiperidine hydrobromide. Stirred with water, decolorized with activated carbon at 40-45℃, filtered out activated carbon, neutralized with alkali, and precipitated white crystals. The filtered crude product is recrystallized with toluene to obtain the finished product.

 

If you are interested in our products or have any questions, please feel free to contact us!

 

Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

Related Products:2-(difluoromethyl)-1,1,1,2,3,3,5,5,5-nonafluoro-4,4-bis(trifluoromethyl)pentane manufacturer | 4-bromo-1-methyl-5-phenylpyrazole supplier | 3,4-Dibromoaniline producer.