(3R,4S)-tert-Butyl 3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidine-1-carboxylate Cas:201856-57-7

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Product Description:

Product Name: (3R,4S)-tert-Butyl 3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidine-1-carboxylate CAS NO: 201856-57-7

 

Synonyms:             

3-(1-ethoxyethoxy)-2-oxo-4-phenyl-1-azetidinecarboxylic acid tert-butyl ester;

Docetaxel Impurity 48;

3-(1-Ethoxyethoxy)-2-oxo-4-phenyl-1-azetidinecarboxylic acid 1,1-dimethylethyl ester;

 

Chemical & Physical Properties:

Appearance: Liquid

Assay :≥99.0%

Density: 1.16

Boiling Point: 459.6℃ at 760 mmHg

Flash Point: 231.8℃

Refractive Index: 1.532

Vapor Pressure: 1.25E-08mmHg at 25℃

 

(3R,4S)-3-(1-Ethoxyethoxy)-2-oxo-4-phenyl-1-azetidinecarboxylic acid 1,1-Dimethylethyl ester is used as a reagent in the synthesis of abeo-taxane derivatives that possess broad inhibitory effects against proliferation of colon cancer, melanoma, and renal cancer cell lines. (3R,4S)-3-(1-Ethoxyethoxy)-2-oxo-4-phenyl-1-azetidinecarboxylic acid 1,1-Dimethylethyl ester is also used as a reagent in the synthesis of a novel D-ring modified Docetaxel analogue which has proven to have equipotent cytotoxicity in relation to Paclitaxel towards cancer cell lines.

 

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