3-​Pyridinecarboxamide

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CAS No: 98-92-0
Product Name: 3-​Pyridinecarboxamide
Other Name:
3-​Pyridinecarboxamide
Vitamin B3 (Nicotinamide)
Vitamin PP (Nicotinamide)
Pyridine-3-carboxamide
Nicotinic acid amide
Nicotinic amide
Niacinamide
Vitamin-B3
Witamina PP
 
Density: 1.2±0.1 g/cm3
Boiling Point: 257.7±32.0 °C at 760 mmHg
Melting Point: 128-131 °C(lit.)
Molecular Formula: C6H6N2O
Molecular Weight: 122.125
Flash Point: 109.7±25.1 °C
Exact Mass: 122.048012
PSA: 55.98000
LogP: -0.24
Appearance of Characters: powder | white
Vapour Pressure: 0.0±0.6 mmHg at 25°C
Index of Refraction: 1.590
Storage condition: 0-6°C
Stability: Stable. Incompatible with strong oxidizing agents.
Water Solubility: 1000 g/L (20 ºC)
 
Specification
Appearance: white crystalline powder
Solubility: free soluble in water and in ethanol, slightly soluble in methylene chloride
Identification
Melting point: 128.0℃~131.0℃
IR test: the ir absorption spectrum is concordant with the spectrum obtained with nicotinamide crs
Appearance of 5%w/v solution: not more intensely coloured than reference solution by7
Ph of 5% w/v solution: 6.0~7.5
Loss on drying: ≤0.5% 
Sulphated ash/Residueon ignition: ≤0.1% 
Heavy metals: ≤30 ppm
Assay: 99.0%~101.0%
 
Application
As an important organic chemical raw material, nicotinamide has a wide range of uses in the pharmaceutical, cosmetics, food and other industries. In the pharmaceutical industry, nicotinamide is a component of coenzyme I (nicotinamide adenine dinucleotide) and coenzyme II (nicotinamide adenine dinucleotide), which acts as an intermediate hydrogen-transfer agent in many biological redox reactions Role in maintaining the integrity of normal tissues, especially the skin, digestive tract, and nervous system.
Pharmacological research believes that nicotinamide, as a vitamin drug, has anti-inflammatory activity and can directly act on inflammatory mediators. By inhibiting the chemotaxis of neutrophils, it can be used for skin diseases and overcome the problem of antibiotic resistance. For the treatment of cardiovascular disease, for anti-cancer.
In the cosmetics industry, the application of nicotinamide involves whitening, moisturizing, acne removing, and hair washing products. Nicotinamide can effectively inhibit the transfer of melanin cells to keratinocytes, thereby reducing excessive pigmentation and promoting Keratinocytes fall off; Nicotinamide can promote the synthesis of proteins in the epidermal layer and enhance the skin's own defense capabilities.
In the food industry, nicotinamide is widely used as an additive in cakes, dairy products, corn flour, etc. as an important food additive. In addition, nicotinamide can also be used as a biochemical agent, a colorant, a plating brightener, a plant growth regulator, and the like.
Mainly effective on seborrheic dermatitis and eczema, with whitening and activating skin cells.
 
Package: 25kg/drum, can also be designed according to customer requirements.
Storage: Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

3-​Pyridinecarboxamide


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