3α-hydroxy-5α-pregnan-20-one Cas:516-54-1

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Product Description:

Product Name: 3α-hydroxy-5α-pregnan-20-one CAS NO: 516-54-1

 

Synonyms:

(3α)-Allopregnanolone;

Pregnan-20-one, 3-hydroxy-, (3α,5α)-;

3alpha-hydroxy-5alpha-pregnan-20-one;

 

Chemical & Physical Properties:

Appearance: White solid

Assay :≥98.0%

Density: 1.053g/cm3

Boiling Point: 431.2℃ at 760mmHg

Flash Point: 183.9℃

Refractive Index: 1.524

Storage Condition: Store at RT

Vapor Pressure: 0.0±2.3 mmHg at 25℃

Water Solubility: chloroform: 20 mg/mL, clear, colorless

 

Safety Information:

Safety Statements: S22; S24/25

WGK Germany: 3

RTECS: TU4383000

F: 10

 

Allopregnanolone (ALLO), also known as 3α-hydroxy-5α-pregnan-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP), is an endogenous inhibitory pregnane neurosteroid. It is synthesized from progesterone, and is a potent positive allosteric modulator of the action of gamma-amininobutyric acid (GABA) at GABAA receptor. Allopregnanolone has effects similar to those of other positive allosteric modulators of the GABA action at GABAA receptor such as the benzodiazepines, including anxiolytic, sedative, and anticonvulsant activity.

Endogenously produced allopregnanolone exerts a pivotal neurophysiological role by fine-tuning of GABAA receptor and modulating the action of several positive allosteric modulators and agonists at GABAA receptor. The 21-hydroxylated derivative of this compound, tetrahydrodeoxycorticosterone (THDOC), is an endogenous inhibitory neurosteroid with similar properties to those of allopregnanolone, and the 3β-methyl analogue of allopregnanolone, ganaxolone, is under development to treat epilepsy and other conditions, including post-traumatic stress disorder (PTSD).

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

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