2-bromo-N-[(2-bromoethylamino)-[(3-methyl-2-nitroimidazol-4-yl)methoxy]phosphoryl]ethanamine Cas:918633-87-1

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Product Description:

Product Name:

2-bromo-N-[(2-bromoethylamino)-[(3-methyl-2-nitroimidazol-4-yl)methoxy]phosphoryl]ethanamine CAS NO: 918633-87-1

 

Synonyms:

HAP-302;

UNII-8A9RZ3HN8W;

TH-302;

 

Chemical & Physical Properties:

Appearance: Crystalline solid

Assay :≥98.0%

Density: 1.97

Boiling Point: 565.4±60.0℃ (Predicted)

PKa: 0.34±0.70 (Predicted)

Flash Point: 295.7±32.9℃

Vapor Pressure: 0.0±1.5 mmHg at 25℃

Index of Refraction: 1.662

 

Evofosfamide (INN, USAN; formerly known as TH-302) is an investigational hypoxia-activated prodrug that is in clinical development for cancer treatment. The prodrug is activated only at very low levels of oxygen (hypoxia). Such levels are common in human solid tumors, a phenomenon known as tumor hypoxia.Evofosfamide is being evaluated in clinical trials for the treatment of multiple tumor types as a monotherapy and in combination with chemotherapeutic agents and other targeted cancer drugs. TH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug (HAP) of bromo-isophosphoramide mustard. Studies have shown that TH-302 treatment exhibited hypoxia-selective cytotoxicity and DNA dama ge in human cancer cell.

 

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