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Product Description:
Product Name: 10-Hydroxycamptothecin CAS NO: 19685-09-7
Synonyms:
Camptothecin,hydroxy;
Hydroxycamptothecine;
10-OH-camptothecin;
Chemical & Physical Properties:
Appearance: Yellow Solid
Assay :≥99.0%
Density: 1.60
Melting Point: 265-270℃
Boiling Point: 820.7±65.0℃(Predicted)
Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20℃
Safety Information:
HS Code: 2934999090
Safety Statements: S24/25
A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy. (S)-10-Hydroxycamptothecin is a clinical therapy agent against hepatoma.IC50 value:Target:In vitro: In vitro, the 10-hydroxycamptothecin nanosuspensions released the encapsulated drug with nearly zero-order kinetics, and the accumulative release reached 90% within 72 hours. In vitro cytotoxicity assay showed that the 10-hydroxycamptothecin nanosuspensions had significantly enhanced cytotoxicity against HepG2 cells compared to the commercially available 10-hydroxycamptothecin injections [1].In vivo: The in vivo study with H22 tumor-bearing mice and intravenous injection of the drug showed that in contrast to the 10-hydroxycamptothecin injections, the 10-hydroxycamptothecin nanosuspensions exhibited significantly enhanced biodistribution, particularly in the lung (393.40-fold AUC0–24 h, liver (192.35-fold AUC0–24 h, spleen (141.67-fold AUC0–24 h and tumor (64.21-fold AUC0–24 h. The 10-hydroxycamptothecin nanosuspensions also showed improved antitumor therapeutic efficacy over the injections (89.83% vs. 30.56%) .
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