α-Lipoic Acid

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Synonyms:
DL-Thioctic Acid
5-(dithiolan-3-yl)pentanoic acid
6,8-Dithiooctanoic acid
1,2-Dithiolane-3-pentanoic acid
(±)-1,2-Dithiolane-3-pentanoic acid
DL-Thioctic acid
5-(1,2-Dithiolan-3-yl)pentanoic acid
DL-α-Lipoic acid
DL-6,8-Thioctic acid
(±)-α-Lipoic acid
 
 
Molecular Formula:  C8H14O2S2
Molecular Weight: 206.32600
 
Appearance and properties: light yellow to yellow powder
Density: 1.218g/cm3
Boiling point: 362.5ºC at 760 mmHg
Melting point: 60-62ºC
Flash point: 173ºC
 
Stability: Stable. Incompatible with strong oxidizing agents.
Storage conditions: 2-8ºC
Applications: α-Lipoic Acid is an antioxidant and an important cofactor for mitochondrial enzyme complex. α-Lipoic Acid can inhibit NF-κB-dependent HIV-1 LTR activation.

 
Items of Analysis Standard of Analysis Test Results
Appearance Yellow crystalline powder Conform
Melting point 60.0-62.0℃ 61.0-61.5℃
Identification IR Conform
HPLC Conform
Optical Rotatuon -1°~ +1°
Related Substances Impurity A: NMT 0.2% N.D
Unspecified Impurity: NMT 0.1% 0.06%
Total impurities: NMT 0.3% 0.08%
Polymer Impurity B: NMT 1.0% Conform
Residual Solvents Cyclohexane: NMT 0.388% 0.262%
Ethyl Acetate: NMT 0.5% N.D
Toluene: NMT 0.089% N.D
Loss on drying NMT 0.2% 0.1%
Residue on Ignition NMT 0.1% 0.06%
Heavy Metals NMT 10ppm Conform
Assay 99.0~101.0% 99.3%
Conclusion Conforms to Factory Standard
 


α-Lipoic Acid


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